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1) Antioxidant effects: populin is a strong antioxidant and oxidative stress plays a key role in various neurological disorders including local ischaemia and age-related dementia. Populin acts through conformational changes to reduce the production and toxicity of β-amylase, which can be used to statistically determine the progression of dementia.Порошок мирицетина 98% (50 мг, C₁₅H₁₀O₈)
2) Anti-tumour effects: populin is a potent chemopreventive agent for carcinogenic effects.Myricetin-Pulver 98% (50mg, C₁₅H₁₀O₈)
3)Reducing neurotoxicity: populin can inhibit the neurotoxicity caused by glutamate through different pathways to protect neurons, thus effectively stopping nerve damage.Polvo de miricetina 98% (50mg, C₁₅H₁₀O₈)
(4) Effect on lymphocyte activation and proliferation: populin can inhibit the expression of CD69, an early activation indicator of T-cells, and inhibit the proliferation response of lymphocytes.Pó de miricetina 98% (50mg, C₁₅H₁₀O₈)
(5) Antagonism of platelet-activating factor (PAF): populin inhibited PAF-induced WRP aggregation and 52HT release in vitro in a concentration-dependent manner. At the same time, it can significantly inhibit the increase of free calcium in platelets caused by PAF. Therefore, populin has various cardiovascular pharmacological effects such as antithrombotic, anti-myocardial ischaemia, and improvement of microcirculation.Poudre de myricétine 98% (50mg, C₁₅H₁₀O₈)
(6) Hypoglycaemic effect: Yangmeiin has more obvious hypoglycaemic effect.
(7) Hepatoprotective effect: dihydromyricetin can significantly inhibit the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and reduce the serum total bilirubin, there is an obvious enzyme lowering and yellowing effect.
What is the difference between trehalose and quercetin?
Studies have shown that populin is highly effective because of its strong free radical scavenging and metal chelating properties, while quercetin is less active in scavenging free radicals, although it also has metal chelating activity.
What is the mechanism of action of populin?
By stimulating Akt and Nrf2, populin inhibits (i) OGD/R-induced inflammation, reduces the expression, phosphorylation and activity of eNOS, decreases the intracellular BH4/BH2 ratio, and lowers intracellular GSH levels in endothelial cells; and (ii) inhibits glutamate-induced nucleus fragmentation and cell death in primary cells.
Preparation of Myricetin.
Dihydromyricetin is mixed with alcohols, then sodium hypochlorite solution and catalyst are added, and after the reaction is complete, sodium hypochlorite solution is continued to be added to obtain myricetin. In this method, the alcohol is methanol or ethanol and the catalyst is anhydrous aluminium trichloride or anhydrous ferric trichloride. This method takes dihydromyricetin as the starting material and prepares the product, populin, after semi-synthesis; since dihydromyricetin is obtained from the plant Garcinia cambogia with a content of more than 98%, the cost is low, the operation is simple, the product yield is high, and the product does not need to be refined, with a content of more than 98%, which is applicable to the industrialised production.
Uses of Myricetin.
Yangmeiin is a flavonoid compound extracted from the fruit of Yangmei, which has various effects such as scavenging free radicals, antioxidant, anti-tumour, reducing neurotoxicity, affecting lymphocyte activation and proliferation, anti-platelet activating factor, lowering blood glucose, relieving alcohol intoxication, preventing alcoholic liver, fatty liver, inhibiting the deterioration of hepatocytes, lowering the incidence of hepatocellular carcinoma, liver protection, anti-inflammatory and so on, and it can also strongly inhibit the yeast α-gluc( It can also strongly inhibit yeast α-glucosidase, glucosidase I, in vitro glucosidase I and xanthine oxidase in milk.
Characteristic | Myricetin | Quercetin |
---|---|---|
Chemical Structure | Extra hydroxyl group | Basic flavonol |
ORAC Value | 32,000 μmol TE/g | 28,000 μmol TE/g |
Food Sources | Bayberries, blackberries | Onions, apples |
Bioavailability | ~40% | ~20% |
Blood-Brain Barrier | Excellent penetration | Limited |
FAQ.
Q1: Can it be taken long-term?
It is recommended to follow a “take for 3 months, stop for 1 month” cycle strategy to avoid receptor desensitization.
Q2: Which is more effective against COVID-19?
Research shows that the inhibition rate of 3CL protease by Yangmei flavonoids (82%) is higher than that of quercetin (68%).
Q3: How to determine product quality?
Check the HPLC test report (Yangmei flavonoids should have a purity of ≥95%)
Choose products with bioavailability-enhancing technology
Product Safety and Compliance Details
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