Natural Losartan raw Materials Powder Losartan

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Losartan Powder Usage and Synthesis.

Losartan is an angiotensin II receptor blocker and a antihypertensive drug. Its antihypertensive effect is mainly through blocking the angiotensin II receptor subtype AT1 in tissues, and more fully and effectively blocking the water and sodium retention, vascular constriction and tissue remodeling effects of angiotensin II. It is clinically suitable for hypertensive patients with insulin resistance, diabetes, cardiac insufficiency, heart failure, myocardial infarction, and can prevent the progression of kidney disease and reduce proteinuria, but it is prohibited for pregnant women.

Uses of Losartan.

Losartan potassium, sold under the brand name Cosuya, is a drug used to treat essential hypertension in patients treated with combination medications. They are Angiotensin II Antagonists. It can be used with other antihypertensive drugs, and can be taken with or without food. Clinical trials have found that this product is well tolerated: adverse reactions are mild and transient, and generally do not require termination of treatment. The overall incidence of adverse reactions was similar to that of placebo.

Pharmacological action of Losartan.

Losartan is an angiotensin II receptor (AT1) blocker. There are two subtypes of the angiotensin II receptor, AT1 and AT2. AT1 receptors were mainly distributed in vascular smooth muscle and myocardial tissue, and AT2 receptors were mainly distributed in adrenal medulla and other parts. Blocking AT1 receptor can reduce peripheral resistance and blood volume, and reduce blood pressure, and the antihypertensive effect is similar to enalapril.

Product Method of Bulk Losartan Powder.

After stirring 2-butyl-4-chloro-5-hydroxymethylimidazole (I) and methanol solution of sodium methylate for 0.5h, the resulting sodium salt and 4 '-bromo-methyl-2-cyanobiphenyl (II) were stirred in dimethylformamide overnight to obtain compound (III). (Ⅲ) is converted into compound (Ⅳ) by a two-step reaction. Compound (V) was obtained by mixing sodium azide and dimethylformamide containing ammonium chloride at 100 ° C for 2 days and then at 120 ° C for 11 days. Finally, losartan was obtained by acid hydrolysis.

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