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Drug development: ergosterol as a component of fungal cell membrane, its structure is stable and highly specific, can be measured by detecting the content of ergosterol to measure the biomass of fungi. In addition, ergosterol can enhance the ability of human body to resist disease. is an important source of fat-soluble vitamin D2. has obvious antibacterial and antitumor effects. its conversion vitamin D2 can be added to feed as a feed additive to increase the laying rate and hatching rate of livestock and poultry. ergosterol can also be used as an important pharmaceutical chemical raw material, used in the production of "cortisone", "hormone progesterone" and other sterol drugs.
Biomass measurement: Because of the representative role of ergosterol in fungal cell membranes, is more representative than glucosamine, can therefore measure fungal biomass by detecting ergosterol content.
Feed additive: converted vitamin D2 can be used as a feed additive, to increase the laying rate and hatching rate of livestock and poultry.
Antifungal agent research: In the antifungal agent research, ergosterol as the main component of fungal cell membrane, combined with the antifungal agent causes ergosterol to be extracted from the cell membrane, thereby killing the fungus. By modifying antifungal agents, reduced toxicity in humans and increased clinical efficacy and safety.
Uses of Ergosterol.
A biological precursor of vitamin D2, found in the cell membranes of fungi and some protists such as Trypanosoma. Ergosterol can be used to study the function of antifungal drugs such as amphotericin B and its analogues and to study the biosynthetic pathway of ergosterol in various fungi.
Preparation of Ergosterol.
Product Method of Bulk Ergosterol Powder.
The dry yeast powder was extracted from the raw paste of yeast through a 60-80 mesh sieve, and then leach with 3x amount of 82-84% ethanol for 18-24h, kept at 70℃ for 3h, stirred continuously, cooled to below 30℃ for filtration, leach the filter residue for 2 times, throw out the ethanol, combine the extraction solution, and concentrate under vacuum at 70℃ for no more than 24h to obtain paste. The filter residue is used to extract ribonucleic acid and yeast polysaccharides.
Dry yeast or ground fungus [ethanol]→[first 68-70℃, then below 30℃] extraction solution [concentrated at 70℃]→ Preparation of paste ergosterol crude paste add 5%-10% water, add 3-5 times the amount of ether, stir vigorously for 2-3h, leave for 16-20h, discard the middle and lower layers of liquid, The upper ether solution was placed in the refrigerator at -5℃ for 20-24h, and ergosterol crystals were precipitated. Paste [ether]→ upper ether solution [-5℃]→[20-24h] crude ergosterol.
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