Camptothecin Raw Materials powder Camptothecin

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Camptothecin powder Usage and Synthesis.

Camptothecin is mainly used for digestive tract tumors. It has good efficacy for gastric cancer, rectal and colon cancer, and can increase the chance of surgical resection of advanced gastric cancer.

It has certain efficacy for cylindrical adenocarcinoma of the head and neck, bladder cancer and lung adenocarcinoma. It can shrink tumors for primary liver cancer. Intravenous injection of camptothecin emulsion can increase the chance of surgical resection of liver cancer. It is also effective for malignant hydatidiform mole and choriocarcinoma. Antitumor alkaloid.

It binds irreversibly to the DNA-topoisomerase I complex, inhibits the rebinding of DNA after topoisomerase I cleavage, and forms a covalent connection between the enzyme and DNA. A cytotoxic antitumor drug.

Uses of Camptothecin powder.

Camptothecin binds irreversibly to the DNA topoisomerase I complex, affecting the cell cycle process and can be used as an anticancer drug. It is used for gastric cancer, colon cancer, rectal cancer, head and neck cylindroma cancer and bladder cancer.

It is used to treat gastric cancer, intestinal cancer, chronic myeloid and acute leukemia, etc.

Pharmacological effect of Camptothecin powder.

Product Method of Bulk Camptothecin powder.

This product is an alkaloid extracted from the root, bark and fruit of the plant Eclipta genus of the Davidiaceae family. It can also be produced synthetically. Soak the crude powder of the fruit of the tree of life in 10 times the amount of 80% ethanol for 24 hours, collect the percolation liquid, and concentrate under reduced pressure to recover the ethanol.

The concentrate is allowed to stand to take the clear liquid, which is extracted with chloroform. The extract is distilled to recover the chloroform until dry, and then methanol solution is added. Cool and filter, and the filter cake is the crude product of camptothecin. The crude product is recrystallized with a methanol-chloroform mixed solvent to obtain camptothecin. For the herbal drug Camptothecin juice, the total yield is 0.03-0.04%.

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