Vitamin B4 Raw materials Powder CAS:73-24-5

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Vitamin B4 Powder Usage and Synthesis.

Adenine is a component of nucleic acids and is involved in RNA and DNA synthesis in living organisms. It promotes leukocyte proliferation when leukocytes are deficient, and is used to prevent and treat leukopenia, as well as in acute granulocytopenia.

Uses of Vitamin B4.

It is a component of nucleic acids, involved in RNA and DNA synthesis in organisms, and promotes leukocyte proliferation when leukocytes are deficient. It is used against leukopenia and also in acute granulocytopenia. It is also used for blood storage.

Note: Since this drug is a nucleic acid precursor, it should be considered whether it has the potential to promote tumor development when used in conjunction with tumor radiotherapy or chemotherapy. It should be dissolved in 2 ml of disodium hydrogen phosphate buffer and injected slowly, not mixed with other drugs.

Preparation of Vitamin B4.

A novel method for synthesizing adenine, comprising the following steps:

(1) firstly dispersing acetyl hypoxanthine in 1,2-dichloroethane, and then adding it to the reactor, slowly putting in anhydrous pyridine and triethylamine, stirring to raise the temperature to 110°C-120°C, adding trichlorophosphorus to hold the reaction for 50-80 minutes, and then continuing to 110°C-120°C to hold the reaction for 4-6 hours and then lowering the temperature to about 15°C, and static until overnight;

(2) The above reaction solution was filtered, and then added into the ammonia/methanol mixture for ammonolysis, drying to obtain the adenine crude product;

(3) Put the obtained adenine crude into the reaction kettle, after the end of feeding temperature rise to 80 ° C to dissolve clear, to be adenine all dissolved to add activated carbon for decolorization, continue 80 ° C heat preservation decolorization for 2 hours, filtration separation of activated carbon;

(4) After filtration, ammonia, crystallization, filtration, washing with a small amount of distilled water, drying, that is, adenine pure product.

Product Method of Bulk Vitamin B4 Powder.

4,6-dichloro-5-nitropyrimidine was ammoniated with ammonia to obtain 4,6-diamino-5-nitropyrimidine, which was then cyclized with formic acid, formamide and sodium thiosulfate to obtain

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