Diindolylmethane Raw Materials CAS:1968-05-4

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Diindolylmethane Powder Usage and Synthesis.

Diindolylmethane (DIM) is a chemical that can be found in a variety of vegetables such as broccoli and cauliflower. It is a potent androgen receptor antagonist that balances estrogen metabolism. Depending on the dose used, it can effectively increase or decrease estrogen in the body.

Studies have shown that DIM accelerates wound healing and is therapeutic in hormone-mediated cancer treatments such as breast, prostate and cervical cancer. In addition, it can inhibit bacterial function, thereby accelerating wound healing. However, further research is needed for its specific application and dosage .

Uses of Diindolylmethane.

Pharmaceutical intermediates; found in natural phytochemicals belonging to the cruciferous family of plants; acid-catalyzed reaction product, indole-3-methanol; possesses antitumor agent properties; this derivative, at relatively high concentrations, both directly accelerates apoptosis and sensitizes TRAIL-induced apoptosis in human cancer cells; DIM induces a G1-cell cytosolic inhibition, which is expressed in human breast cancer MCF-7 cells, by mechanism, containing expression; DIM is a potent inhibitor of mitochondrial H+-ATPase; DIM and its derivatives function as new plant growth promoters and have been utilized in the study of eco-friendly systems.

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Preparation of Diindolylmethane.

Indole (1.17 g,10 mmol), CTAB (50% mol) and oxalic acid (50% mol) were placed in a 25 ml single mouth round bottom flask, 5 ml of deionized water was added and stirred thoroughly for 5 min, then an aqueous solution of formaldehyde was added dropwise (0.38 g of solution, 5 mmol of formaldehyde).

The reaction was stopped for 3 hours at room temperature. The reaction solution was extracted with 15 ml of ethyl acetate in three portions and the organic phase was collected and dried with anhydrous Na2SO4 for 5 hours. The solvent was removed under reduced pressure and recrystallized from a mixed solution of methanol and water (methanol/H2O = 10/1) to give 3,3'-diindolylmethane as a white solid in 85% yield.

Product Method of Bulk Diindolylmethane Powder.

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