Limonin Raw Materials Limonin Powder

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Limonin Powder Usage and Synthesis.

The study of citrulline analogues was initiated to remove them from citrus fruits with the aim of increasing the commercial value.

However, with the continuous and in-depth research on the physiological activities of citrulline analogues, research on their recovery from citrus in large quantities, their refinement and their application have also received more and more attention.

Citrinin analogues have physiological activities such as cancer inhibition and should be developed as functional food materials. microherb has successfully isolated 98% pure citrinin using advanced chromatographic separation technology after years of research, which is widely used in pharmaceuticals, functional food supplements and biopesticides.

Uses and functions of Limonin.

For the determination of citrinin in citrus products

Exhibits anti-proliferative and anti-apoptotic activity against several tumour cell lines and inhibits oxidized azoxymethane (azoxymethane)-induced colon cancer in rats.

Inhibits HIV-1 virus replication in monocytes, macrophages and monocytes by inhibiting HIV-1 protease activity.

Pharmacological Effect of Limonin Powder.

(1) Analgesic and anti-inflammatory effects There have been studies on the isolation of citrulline from Cornus officinalis and the corresponding experimental studies. For example, it was found that the number of foot licking in mice was significantly reduced by administering 100 mg/kg of citrulline.

Meanwhile, experimental studies conducted by lemon bitterin analogue on vascular permeability of acetic acid channel, on bradykinin-induced foot swelling response, and on arachidonic acid-induced ear swelling found that the product has obvious analgesic and anti-inflammatory effects.

(2) Anxiolytic and sedative effects on the hypnotic test of anaesthetised mice found that lemon bitterin, nomylin, orbacholone, 7 an orbacholone, 70r a lemon bitter alcohol and other lemon bitterin compounds are able to prolong the sleep time of mice induced by the slang monochloralose and uralactan, of which the compound nomylin has a stronger sedative effect.

(3) Insect prevention and killing activity about lemon bitterin analogues feeding deterrent, from the dong tree (Azadirachtaindica) seeds isolated from the indo-bitter dong ZiZiZi activity is high, on more than 60 kinds of insects have the effect.

Citrus citrinin analogues (obakone, nomilin, citrinin) also showed activity against insects and termites. It is of great significance to develop and utilise these natural citrinin analogues as biological pest control agents.

(4) In addition to the above biological effects, it also has antioxidant activity, antimicrobial activity, inhibition of HIV, lowering cholesterol, obvious diuretic effect, improve cardiovascular circulation and sleep, anti-virus, regulation of cytochromes, etc., which has a very good health care function.

Synthetics of Bulk Limonin Powder.

The current main method for the domestic synthesis of citracones by biological means starts from the glycyrrhizidine or halothane-type triterpenoids, and goes through methyl migration, oxidation, and side-chain ring amalgamation with the removal of four Cs to form the basic skeleton, and then undergoes a series of post-modification reactions to form the structurally complex and richly varied type of a class of natural products, which are also known as tetradecanoic triterpenoids, because of their origin from tetracyclic triterpenoid skeletons and loss of the four Cs.

Structurally complex neem citrullines have not only attracted the attention of natural product chemists, but also challenged organic synthesis techniques.

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