Asiaticoside Raw Materials Asiaticoside Powder

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Asiaticoside Powder Usage and Synthesis.

Asiaticoside is the main component in the herb Centella asiatica, and the mixture of Asiaticoside A and Asiaticoside B has pharmacological effects such as promoting wound healing, anti-wrinkle, anti-inflammatory, antidepressant, and promoting intelligence.

Comparison of the pharmacological effects of Centella asiatica glycosides to promote wound healing, treatment of scars can be found, the total saponins of Centella asiatica anti-inflammatory, antidepressant, promote intelligence and other pharmacological effects may be Centella asiatica glycoside A and Centella asiatica glycoside B played a major role.

Uses of Asiaticoside.

Promote wound healing, stimulate the growth of granulation, treatment of various skin diseases.

Asiaticoside belongs to the pentacyclic triterpenoids and has various pharmacological effects such as antiulcer, wound healing, anti-tumour, anti-inflammatory and immunomodulation. It is currently used in the treatment of scleroderma and skin wounds and burns.

Preparation method of Asiaticoside.

Weigh 500g crushed Centella asiatica powder, with 2500ml mass concentration of 75% ethanol aqueous solution immersion, ultrasonic extraction under the condition of 50 ℃ for 4 times, each time 1 hour, filtration, the filtrate will be combined and concentrated under reduced pressure to get 20.5g of the extract;

Dissolve the extract with 200ml of water, extract with an equal volume of aqueous solution of the extract of petroleum ether for 3 times, and the lower phase of the aqueous solution and then an equal volume of ethyl acetate extraction for 4 times, and bring together the lower phase of the aqueous solution.

With the collection of the lower phase of the aqueous solution of the same volume of n-butanol and ethyl acetate volume ratio of 1:1 mixed solvent extraction 3 times, combined with the upper phase of the extract, with activated carbon decolourisation of the extract, decolourisation of the extract after concentration under reduced pressure to obtain the total glycosides of Centella asiatica 7.3g;

Add 10 times the amount of methanol to dissolve the total glycosides of Centella asiatica, filtration, filtrate concentration, and then use the mass concentration of 90% ethanol aqueous solution at room temperature recrystallisation to obtain high-purity Centella asiatica glycosides 3.3g, purity of 90%, the yield rate of 0.66%.

Caveat of Bulk Asiaticoside Powder.

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