Biochanin A Raw Materials Biochanin A Powder

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Biochanin A Powder Usage and Synthesis.

Biochanin A (BCA) is an oxymethylated isoflavonoid widely found in some edible plants, such as soybean, red clover, alfalfa, peanut and chickpea, etc. Especially, the highest content is found in red clover, but it is only 833mg/100g.

It has an oestrogen-like effect, inhibits the rise of cholesterol, and also has antifungal and antitumour effects. Hormone levels in the body has a two-way regulatory effect. There are also anticancer antispasmodic hypolipidemic effect.

Uses and functions of Biochanin A.

The molecular structure of BCA is similar to that of animal estrogen, and it can competitively bind to estrogen receptor to exert estrogen-like effects. It is an important phytoestrogen, which has various beneficial effects on human and animal health, and it can be used in the prevention and treatment of osteoporosis, menopausal syndrome and other diseases.

Besides, it also has various pharmacological effects such as anti-tumour, anti-inflammatory, antibacterial, hypoglycemic, antioxidant and neuroprotective.

Preparation of Biochanin A Powder.

CN201610575057.3 provides a method for synthesising chickpea sprue A, which mainly solves the problems of complicated synthesis process and low yield in the prior art.

It includes the following steps:

Step 1 Preparation of intermediates Under room temperature conditions, phosphorus oxychloride is added to m-triphenol, p-methoxybenzeneacetonitrile and isopropyl ether, and when the reaction is complete, an appropriate amount of water is added to hydrolyse it, and activated charcoal is used for decolourisation, i.e. the intermediates are obtained;

Step 2 preparation of crude product the intermediate obtained in step 1 and methanesulfonyl chloride in N, N-dimethylformamide (DMF) off the ring to generate chickpea shootin A crude product;

Step 3 refining the chickpea sprouts A crude product obtained in step 2 was recrystallised using ethanol and decolourised by activated carbon to obtain chickpea sprouts A.

In vitro studies of Bulk Biochanin A Powder.

BiochaninA was reported to inhibit protein tyrosine kinase (PTK) of the epidermal growth factor receptor with an IC50 value of 91.5 μM.

BiochaninA inhibited the hydrolysis of 0.5 μM cannabinoids by fatty acid amides (FAAH) in mice, rats, and humans with IC50 values of 1.8, 1.4, and 2.4 μM, respectively.

BiochaninA was able to inhibit the growth of serum- and EGF-stimulated LNCaP and DU-145 cells (IC50 values ranged from 8.0 to 27 μg/ml for serum and 4.3 to 15 μg/ml for EGF), but had no significant effect on the autophosphorylation of EGF receptor tyrosine.

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