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As fluoxetine is the first 5-HT reuptake inhibitor antidepressant on the market, it has a different structure and pharmacological mechanism from previous TCAs antidepressants.
With its precise efficacy and mild side effects, it has been favoured since its introduction to the market, and its sales have increased significantly year after year.
Since the 1970s, when Eli Lilly and Company developed fluoxetine, it has created a number of brilliant, a generation of legend, opening up a new chapter in the treatment of depression medication.
Although the market declined after 2001, but is still one of the commonly used drugs for antidepressant treatment.
Fluoxetine hydrochloride can be used for all types of depression, especially for depressive symptoms associated with organic disease and depression in old age. It is also used to treat post-schizophrenic depression.
It is also used for obsessive-compulsive disorder, phobias, anxiety symptoms of depression, bulimia nervosa, weight loss and as an adjunctive treatment for smoking cessation.
Uses of Fluoxetine Hydrochloride.
Fluoxetine hydrochloride can be used for all types of depression, especially for depressive symptoms associated with organic disease and depression in old age. It is also used to treat post-schizophrenic depression.
It is also used for obsessive-compulsive disorder, phobias, anxiety symptoms of depression, bulimia nervosa, weight loss and as an adjunctive treatment for smoking cessation.
Pharmacological Effect of Fluoxetine Hydrochloride.
Fluoxetine blocks 5-HT2A receptors and restores DA and NE levels through inhibition of 5-HT2A receptors. At the same time, fluoxetine also relieves the inhibitory effect of gamma-aminobutyric acid (GABA) neurons on NE and DA release via 5-HT2C receptors.
In addition to its ability to increase the 5-HT concentration in the synaptic gap, it is based on fluoxetine's action on 5-HT2A and 5-HT2C that directly and indirectly restores the levels of DA and NE, with NE and DA derepression properties (NDDI).
Adverse Reaction of Bulk Fluoxetine Hydrochloride Powder.
The main adverse effects of fluoxetine hydrochloride are nausea, nervousness and insomnia, which disappear on their own after stopping the drug. Other side effects are headache, anxiety, excessive sweating, diarrhoea, blurred vision, dry mouth and sexual dysfunction.
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