Pharmaceutical raw material Ivermectin Powder

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Ivermectin Powder Usage and Synthesis.

Ivermectin is a new broad-spectrum, highly effective, low-toxicity antibiotic antiparasitic drug, which has good anthelmintic effects on both internal and external parasites, especially nematodes and arthropods. However, it is ineffective against tapeworms, trematodes and protozoa.

The anthelmintic effect of macrolides on nematodes and arthropods is to increase the release of inhibitory transmitter γ-aminobutyric acid (GABA) in worms, as well as to open the Cl ion channel controlled by glutamate, to enhance the permeability of the nerve membrane to Cl, thus blocking the transmission of nerve signals, and eventually nerve paralysis, so that muscle cells lose the ability to contract, thus resulting in the death of the worms.

Ivermectin is widely used against gastrointestinal nematodes, lung nematodes and parasitic arthropods in cattle, sheep, horses and pigs, intestinal nematodes, ear mites, scabies mites, heartworms and microfilariae in dogs, and gastrointestinal nematodes and ectoparasites in poultry.

Uses and functions of Ivermectin.

Ivermectin is a derivative of avermectin and is an oral, semi-synthetic, broad-spectrum antiparasitic drug. It is effective against most, but not all, nematodes of all life cycles; against microfilariae of Onchocerca volvulus, but not against adult worms; and against faecal roundworms, which are only found in the gut. 

Ivermectin has a selective inhibitory effect, by binding with high affinity to the glutamate-valved chloride channels in the nerve cells and muscle cells of anurans, which leads to an increase in the permeability of the cell membrane to chloride ions, causing hyperpolarisation of the nerve cells or muscle cells, and paralysis or death of the parasites.

Ivermectin also interacts with chloride channels of other ligand valves such as the neurotransmitter g-aminobutyric acid (GABA). 

The selectivity of ivermectin is due to the absence of glutamate-chloride channels in some mammals and the fact that avermectin has only a low affinity for mammalian ligand-chloride channels.

Ivermectin does not penetrate the human blood-brain barrier. Onchocerciasis and onchocerciasis-like nematodes and hookworm, roundworm, whipworm, and pinworm infections. Death.

Drug interactions of Ivermectin.

Ivermectin commercial preparations containing different adjuvants can affect the action of the drug, such as internal administration of sheep containing Tween-80 as an adjuvant to the preparation, ivermectin dosage of up to 4,000 μg / kg, is still very safe, but if the propylene glycol to do the adjuvant, the sheep continued for three days to ataxia and haemoglobinuria.

In the United States, ivermectin injection containing Tween-80 as adjuvant is a commercial preparation for equine animals, but it cannot be used in dogs, otherwise it is also extremely unsafe.

Production method of  Bulk Ivermectin Powder.

Obtained by hydrogenation of the corresponding compound (I) in benzene, tris(triphenylphosphine)rhodium chloride catalysed at room temperature under atmospheric pressure.

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