Pharmaceutical raw material L-Histidine Powder

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L-Histidine Powder Usage and Synthesis.

The product form of L-Histidine is white powdery crystal. It is an important amino acid raw material drug, is a kind of human body semi-essential amino acid, mainly used as amino acid infusion and oral amino acid preparation raw materials; In addition, it is also an important drug for the treatment of heart disease, anaemia, rheumatoid arthritis, peptic ulcer and substantial hepatitis, etc., which is being more and more widely used in the field of medicine.

Uses of L-Histidine.

Amino acid drugs. The main ingredient of amino acid infusion and comprehensive amino acid preparation, used for the treatment of gastric ulcer, anaemia and cardiovascular system disorders such as angina pectoris, aortitis and cardiac insufficiency. Adverse reactions and contraindications: low toxicity, adult toxicity >64g/day. If histaminic acid hydrochloride injection has headache, flushing, hot feeling

Used as a nutritional enhancer, is an important component of amino acid infusion, compound amino acid preparations. Can be used to treat gastric ulcer. Also used in biochemical research.

Nutritional supplements. Extremely important component of amino acid infusion and comprehensive amino acid preparations. Used in medicine to treat gastric ulcers, anaemia, allergies, etc.

Characteristic of L-Histidine.

L-Histidine is colourless needle or flake crystal, softened at 277°C, decomposed at 287°C. Solubility in water at 25°C is 41.9g/L, very slightly soluble in alcohol, insoluble in ether and chloroform. Sweet taste

White crystal or crystalline powder. Odourless. Slightly bitter taste. Melts and decomposes at 277-288℃. Its imidazole group is easy to form complex salts with metal ions. Soluble in water (4.3g/100ml, 25℃), very difficult to dissolve in ethanol, insoluble in ether. Because of the very small solubility and other reasons, commonly used for its hydrochloride.

Production methods of Bulk L-Histidine Powder.

Extracted from pig blood and cow blood. Porcine blood was spray dried to produce blood powder, about 18kg of blood powder per 100kg of porcine blood.L-Histidine is commonly used as its hydrochloride ([7048-02-4]).

The eluate containing L-histidine, concentrated until the appearance of crystals, while hot with hydrochloric acid to pH 2.5, immediately add 2 times the amount of solution of ethanol, static, precipitation, filtration, that is, L-histidine hydrochloride crude, after decolourisation, recrystallisation, drying to get the finished product.

L-Histidine can also be extracted from the hydrolysis product of defatted soybean.

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