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Oleanolic acid is a pentacyclic triterpenoid compound isolated and extracted from the fruits of green leaf gall bladder or chasteberry of the genus Swertia in the family Gentianaceae, which exists in a variety of plants in free form and ligands, and has become a commonly used hepatoprotective drug in clinics, with obvious protective effects on carbon tetrachloride-induced acute and chronic hepatic damage in rats, which can make the elevated ALT and AST drop, reduce inflammation, necrosis and interstitial inflammation, prevent fibrosis from forming, promote regeneration of hepatocytes, and accelerate recovery of necrotic tissues.
Uses and functions of Oleanolic acid.
With liver protection and enzyme reduction, promote liver cell regeneration, anti-inflammatory, cardiotonic, diuretic, anti-tumour and other effects, but also has the role of hypoglycemia, hypolipidemic, sedative, is the treatment of liver disease and hypoglycemia and other drugs such as the effective ingredients.
Clinically used in the treatment of infectious acute jaundice hepatitis, with a significant reduction of gammaglutamic enzyme and the effect of yellowing, improve the symptoms, signs and liver function of patients with viral and chronic prolonged hepatitis; can also be used for psoriasis, rheumatoid arthritis, nephritis oedema, cirrhosis of the liver and ascites, acute and chronic hepatitis, gastric pain and gonorrhoea, haematochezia, bruises, carbuncles, lumbar and knee soreness, foetal restlessness and other diseases.
Function of Oleanolic acid.
1, oleanolic acid has anti-inflammatory, sedative, cardiotonic, diuretic, hypolipidemic, hypoglycemic as well as hepatoprotective and enzyme-lowering, enhancement of immunity and inhibition of the growth of S180 tumour strains and other roles, it is the development of the treatment of liver disease and hypoglycemic and other effective components of the drug.
2, oleanolic acid has a protective effect on chromosome damage, and has a preventive effect on experimental atherosclerosis. Clinically used in the treatment of infectious acute jaundice hepatitis, chronic viral hepatitis, with a significant reduction of ghrelin and yellowing effect.
3, oleanolic acid has the effect of inhibiting hepatic fibroplasia, by oleanolic acid treatment of hepatic fibrosis in rats, hepatic fibroplasia is serious and obviously reduce the hepatic collagen content, suggesting that it has the effect of preventing and controlling cirrhosis of the liver.
4, reduce the cirrhotic rat brain homogenate kojic acid level: due to the brain homogenate kojic acid level decreased significantly, can inhibit the generation of pseudo-neurotransmitter, so it is conducive to the prevention and treatment of hepatic encephalopathy.
5, oleanolic acid capsules for liver disease adjuvant drugs class of non-prescription drugs, for acute and chronic hepatitis adjuvant therapy. It has a certain protective effect on liver injury, can make the elevated serum alanine aminotransferase decrease, promote liver cell regeneration, accelerate the repair of necrotic tissue.
Clinical applications of Bulk Oleanolic acid Powder.
Oleanolic acid is an anti-hepatitis drug, clinically it is mainly used for the treatment of acute jaundice hepatitis, with remarkable efficacy, and also has a good effect on chronic hepatitis. It has obvious improvement on symptoms, signs and liver function. In addition, there is a role in correcting protein metabolism disorders
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