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O-Desmethylvenlafaxine is a 5-hydroxytryptamine (5-HT)-norepinephrine (NE) reuptake inhibitor.Desmethylvenlafaxine Powder is the first FDA-approved treatment for major depressive disorder of the SNRI venlafaxine [venlafaxine, trade name: EfexorXR (EfexorXR)]'s demethylated active metabolite.O-Desmethylvenlafaxine Raw Material
A 5-hydroxytryptamine-norepinephrine reuptake inhibitor and the active metabolite of the antidepressant venlafaxine.
Uses and functions of O-Desmethylvenlafaxine Powder.
Norvenlafaxine was well absorbed orally, and the absolute oral bioavailability was 80%. Food had little effect on its absorption, and when taken with low, medium and high fat meals, respectively, only high fat meals increased cmax by about 16%, but there was no significant difference in AUC. In the range of 100 to 600mg/d, DVS single dose oral administration showed linear pharmacokinetic characteristics.
A single oral dose of 100mgDVS, cmax was 376mg/L, tmax was 7.5h, and AUC was 6747mg·h·L-1. The drug was administered once a day and stable blood concentration was reached 4 to 5 days later. The pharmacokinetics of multiple dosing remained linear. The binding rate of DVS to plasma protein in vitro was about 30%. The steady-state distribution volume (Vd) of intravenous administration was 3.4L/kg, suggesting drug distribution into non-vascular areas.
Pharmacological Effects of O-Desmethylvenlafaxine Powder.
Production method of O-Desmethylvenlafaxine Powder.
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