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Product details
Lisinopril can reduce lung wedge pressure, increase stroke volume, increase left ventricular ejection fraction and improve cardiac function in patients with heart failure. It can increase renal blood flow, reduce renal vascular resistance and increase glomerular filtration rate. Use alone or in combination with other drugs to treat various degrees of hypertension and renal hypertension that have failed to be treated with other antihypertensive drugs, can also be used alone or in combination with digitalis and diuretics to treat congestive heart failure. It can also be used as adjuvant therapy for hemodynamic stable patients after acute myocardial infarction.
Lisinopril Dosage Guide
| Condition | Typical Starting Dose | Maintenance Dose | Maximum Dose |
|---|---|---|---|
| Hypertension | 10 mg once daily | 20–40 mg daily | 80 mg daily |
| Heart Failure | 2.5–5 mg once daily | 5–40 mg daily | 40 mg daily |
| Post-Heart Attack | 5 mg within 24 hrs | 5–10 mg daily | 10 mg daily |
Uses of Lisinopril.
The efficacy of lisinopril alone was slightly better than atenolol or hydrochlorothiazide in the treatment of mild and moderate hypertension. In the treatment of severe hypertension, the efficacy is the same as metoprolol or nifedipine; The treatment of congestive heart failure is superior to captopril, and can increase left ventricular ejection fraction, enhance mobility and improve quality of life. At present, this product is a second-line drug for the treatment of hypertension and congestive heart failure.
Pregnant women (can harm the fetus)
Patients with a history of angioedema
Those taking aliskiren (for diabetes/kidney patients)
People with severe kidney disease (dose adjustment required)
Pharmacological action of Lisinopril.
This product is a lysine derivative of enalaprilat and has a strong angiotensin-converting enzyme inhibitory effect. Its characteristic is that it can produce pharmacological effects in vivo without liver transformation, and the effect appears late, but the effect is maintained for a long and stable time.
FAQ.
Q: Can I take Lisinopril with food?
A: Yes, it can be taken with or without food.
Q: How long does it take to work?
A: Blood pressure effects may be seen within 2–4 hours, but full benefits take a few weeks.
Q: Does Lisinopril cause weight gain?
A: No, weight gain is not a typical side effect.
Q: Can I drink alcohol while on Lisinopril?
A: Moderate consumption is usually fine, but alcohol may worsen dizziness.
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