Sennosides Raw Materials Sennosides powder

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Sennosides Powder Usage and Synthesis.

Sennosides are a common herbal medicine with a variety of benefits and effects.

First of all, senna glucoside has a significant laxative effect, can be used to treat constipation, food accumulation and other symptoms.

Studies have shown that senna glycosides on mice, rats, rabbits and other animals and people have significant diarrhoeal effect, mice and rabbits in the 2-4 hours after the drug to diarrhoea, people orally about 6 hours to cause diarrhoea.

Uses of Sennosides.

Sennosides are a common herbal medicine with a variety of benefits and effects.

First of all, senna glucoside has a significant laxative effect, can be used to treat constipation, food accumulation and other symptoms.

Studies have shown that senna glycosides on mice, rats, rabbits and other animals and people have significant diarrhoeal effect, mice and rabbits in the 2-4 hours after the drug to diarrhoea, people orally about 6 hours to cause diarrhoea.

Secondly, senna glucoside also has the effect of clearing heat and detoxification, can be used to treat fever, dysentery and other symptoms. In addition, senna glycosides can also be used to treat hepatitis, jaundice and other diseases.

It should be noted that the dosage of senna glycosides should be determined on a case-by-case basis, and overdose may cause side effects such as facial numbness, dizziness, and urinary retention.

Therefore, senna glycosides should be taken in accordance with medical advice, and the dose should not be increased or decreased arbitrarily.

Pharmacological effect of Sennosides.

1、Hemostatic effect

Effective in gastric and duodenal haemorrhage. Senna leaf aqueous infusion in gastroscopy sprayed on the gastric bleeding, direct vision can be seen to have immediate haemostatic effect. Senna total glucoside 200mg/kg intraperitoneal injection can significantly shorten the bleeding time in mice.

Oral administration of senna leaves can increase the platelet count and fibrinogen content, and shorten the clotting time, thromboplastin time, plasma recalcification time and clot contraction time. In addition, the protective effect of senna on hydrochloric acid and anti-inflammatory pain-induced gastric mucosal damage in rats is also conducive to the prevention and treatment of gastric and duodenal bleeding.

2、Anti-bacterial effect

Senna leaf infusion has an inhibitory effect on a variety of bacteria, such as Escherichia coli, Escherichia contorta, dysentery bacillus, Streptococcus aureus, as well as Candida albicans and certain pathogenic skin fungi.

3、Other effects

In rats with experimental intestinal infarctions, senna glycosides 50 mg/kg intraperitoneally restored the reduced intestinal mucosal histamine content to normal levels. In addition, it has been reported that the product has an arrow poison like effect, which can block the transmission of impulses at the nerve-muscle junction, prevent the binding of acetylcholine to M receptors and cause muscle relaxation.

Characteristic of Sennosides.

Sennoside is a mixture of equal parts of the calcium salts of Sennoside A (Sennoside A) and B (Sennoside B) extracted from the leaves of Sennoside, or directly from Sennoside. This product has a stimulating effect on the wall of the large intestine, reflexively causing an increase in peristalsis and causing defecation. It is suitable for constipation, especially for inducing diarrhoea after taking anthelmintics.

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