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Adenosine Powder is a purine nucleoside, a compound consisting of the N-9 of adenine linked to the C-1 of D-ribose by a beta-glycosidic bond, with the chemical formula C10H13N₅O₄, and its phosphate ester is adenosine acid.Adenosine Raw Materials plays an important role in biochemistry.
It plays an important role in biochemistry, including the transfer of energy in the form of adenosine triphosphate (ATP) or adenosine diphosphate (ADP).
Adenosine CAS 106685-40-9 can be used in the treatment of angina pectoris, myocardial infarction, coronary insufficiency, arteriosclerosis, essential hypertension, cerebrovascular disorders, post-stroke sequelae, and progressive muscular dystrophy.Adenosine Raw Materials is used in the treatment of angina pectoris and myocardial infarction.
Uses and functions of Adenosine Powder.
1.Adenosine can be used to treat angina pectoris, myocardial infarction, coronary insufficiency, arteriosclerosis, essential hypertension, cerebrovascular disorders, post-stroke, progressive muscular dystrophy.
2. Endogenous neurotransmitter. In the pharmaceutical industry, it is mainly used for the manufacture of adenosine adenosine (Ara-AR); adenosine triphosphate (ATP); coenzyme A (COASH) and its series of products cyclic adenosine monophosphate (CAMP) and other major raw materials for drugs.
3. Adenosine induces apoptosis in human leukaemia HL-60 cells. It also has anti-arrhythmic properties. A neurotransmitter, at all subtypes of adenosine A receptors, as the preferred endogenous agonist.
Pharmacological Effects of Adenosine Powder.
Adenosine is a natural nucleotide, an intermediate product of body metabolism, and one of the important active ingredients in the body. Its action is mediated by the activation of adenosine receptors (A receptors).
In the atrium, sinus node and AV node, adenosine activates the G protein-coupled potassium channel by binding to the A receptor, which increases K+ efflux, hyperpolarises the cell membrane and reduces autoregulation.
It can also significantly increase the level of cGMP, prolong the ERP of AV node and slow down the conduction, inhibit the sympathetic nerve or isoprenaline-induced early and late depolarisation and play an antiarrhythmic role. It has not been classified into Class I-IV antiarrhythmic drugs.
Production method of Adenosine Powder.
Adenosine is an inhibitory neuromodulator of the central nervous system that signals an equilibrium between the brain's energy stores and energy demands.
Under normal conditions, the extracellular adenosine concentration is maintained at 40-400 nmo L. When ischemia and hypoxia occur, both glucose and glycogen are accelerated to break down to produce ATP in response to energy demand, and ATP is then degraded, resulting in a dramatic increase in intracellular adenosine levels, which are released into the extracellular compartment to play its regulatory role.
During the recovery phase of hypoxia, endogenous adenosine, as a precursor of ATP synthesis, can be catalyzed by adenosine kinase (AK) to regenerate ATP to prolong the survival time of cells.
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