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Diclofenac Sodium is a white crystalline powder with trade names such as Fu-Talin, Diclofenac, Diclofenac, Diclofenac, etc. Diclofenac Sodium Powder is a non-steroidal anti-inflammatory drug (NSAID) derived from phenylacetic acid.
Diclofenac Sodium Powder is a non-steroidal anti-inflammatory drug (NSAID) derived from phenylacetic acid.
Diclofenac Sodium Raw Material is mainly used for the treatment of osteoarthritis, rheumatoid arthritis, polymyositis, dermatomyositis, spondyloarthropathies, and other diseases. Dicloac Sodium Raw Material is mainly used for the treatment of osteoarthritis, rheumatoid arthritis, polymyositis, dermatomyositis, spondyloarthropathies, ankylosing spondylitis, and other conditions that require acute pain relief.
Uses and functions of Diclofenac Sodium Powder.
Diclofenac Sodium Powder is a colorless crystalline powder. Melting point 283-285°C, free acid melting point 156-158°C. Diclofenac Sodium Powder is a colorless crystalline powder. Diclofenac Sodium is used as an anti-inflammatory and analgesic, mainly for the treatment of osteoarthritis, rheumatoid arthritis, polymyositis, dermatomyositis, spondyloarthropathies, ankylosing spondylitis, gout, as well as migraines, toothaches, gallstones and kidney stones, and other conditions requiring acute pain relief.
Diclofenac sodium is a potent antipyretic, analgesic and anti-inflammatory drug. Its anti-inflammatory effect is 2-2.5 times stronger than that of indomethacin and 26-50 times stronger than that of acetylsalicylic acid. It is suitable for rheumatoid arthritis, osteoarthrosis, post-surgical pain relief and fever of various causes. Standard NSAID as well as cyclooxygenase (COX) inhibitor; used as a selective substrate for CYP2C9.
Pharmacological Effects of Diclofenac Sodium Powder.
1, This product is a non-steroidal anti-inflammatory and analgesic drug derived from phenylacetic acid, and its mechanism of action is to inhibit the activity of cyclooxygenase, thus blocking the conversion of arachidonic acid to prostaglandins. At the same time, it can also promote the combination of arachidonic acid and triglyceride, reduce the concentration of free arachidonic acid in the cell, and indirectly inhibit the synthesis of leukotrienes.
Diclofenac potassium is one of the stronger non-steroidal anti-inflammatory drugs, and its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and anti-inflammatory pain.
Production method of Diclofenac Sodium Powder.
Synthesis of 2,6-dichlorodiphenylamine:
2,6-Dichlorodiphenylamine was obtained from 2,6-dichlorophenol and aniline by acylation, condensation, Chapman rearrangement and hydrolysis. The three-step reactions of acylation, condensation and rearrangement, except for the recovery of solvents (toluene for acylation, and DMF for condensation and rearrangement), were carried out in a "one-pot" reaction, i.e., in the same reactor, without the need to separate the step-by-step process.
The reaction is reproducible. Synthesis of diclofenac sodium: 2,6-dichlorodiphenylamine and chloroacetyl chloride were used as the main raw materials, and 1-(2,6-dichlorophenyl)dihydroindol-2-one was obtained by acylation and intramolecular Foucault alkylation, and finally, the product, diclofenac sodium, was obtained by alkaline hydrolysis of ring-opening.
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