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Acemetacin Powder Usage and Synthesis:
Acemetacin is a non-steroidal anti-inflammatory analgesic and a prodrug of indomethacin. China Pharmaceutical Api Manufacturer supply Acemetacin Raw Material, wholesale price supply Acemetacin Powder, professional Acemetacin Powder Supplier from China.Acemetacin Raw Material Powder is a non-steroidal anti-inflammatory analgesic and a prodrug of indomethacin. It does not show any pharmacological activity after oral administration, and most of it is absorbed into the liver through the small intestine and converted into indomethacin to show curative effect. It can inhibit the denaturation of inflammatory tissue proteins and the synthesis of prostaglandins, and inhibit the release of hyaluronidase and inflammatory mediators, thereby exerting its anti-inflammatory and analgesic effects. It is suitable for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriatic arthritis, acute gouty arthritis, other chronic polyarthritis, tenosynovitis, bursitis, low back pain, sciatica, etc.
Pharmacokinetics of Acemetacin :
Acemetacin is an anti-inflammatory pain reliever. Acetyl indomethacin is the prodrug of indomethacin, which becomes indomethacin through metabolism in the body to play a role. Because Acemetacin has a strong anti-inflammatory effect and has very little damage to the mucous membrane of the gastrointestinal system, it has a wider range of treatment than indomethacin. Use indomethacin as raw material, react with thionyl chloride in ether-pyridine to generate indomethacin acidic acid chloride, and then react with glycolic acid in dry pyridine to obtain acetyl indomethacin. The yield was 54%. It can also be prepared by the reaction of indomethacin and ethyl chloroacetate in DMF solution.
Clinical Application of Acemetacin :
Acemetacin Powder is used for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriatic arthritis, acute gouty arthritis, chronic polyarthritis, low back pain, sciatica and inflammation of joints, muscles or tendons, Tenosynovitis, bursitis, inflammation and swelling after surgery and after blunt outer fingers, superficial phlebitis, or other vascular inflammation. Non-steroidal anti-inflammatory analgesics, which can significantly inhibit inflammation. Acemetacin Powder is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, myofibroblastitis, sciatica, etc.
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