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Acemetacin Usage and Synthesis:
Acemetacin USP BP EP Powder Raw Material CAS 53164-05-9 Acemetacin Powder Supplier in China, Acemetacin Powder Raw Material is a non-steroidal anti-inflammatory analgesic, a prodrug of indomethacin. , osteoarthritis, psoriatic arthritis, acute gouty arthritis, other chronic polyarthritis, tenosynovitis, burstitis, low back pain, sciatica, etc.
Acemetacin Powder Raw Material is a non-steroidal anti-inflammatory analgesic and a prodrug of indomethacin. It does not show any pharmacological activity after oral administration, and most of it is absorbed into the liver through the small intestine and converted into indomethacin to show curative effect. It can inhibit the denaturation of inflammatory tissue proteins and the synthesis of prostaglandins, and inhibit the release of hyaluronidase and inflammatory mediators, thereby exerting its anti-inflammatory and analgesic effects. Acemetacin Powder Raw Material is suitable for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriatic arthritis, acute gouty arthritis, other chronic polyarthritis, tenosynovitis, bursitis, low back pain, sciatica, etc. .
Pharmacokinetics of Acemetacin:
After oral administration, the main form of indomethacin and a trace amount of acemetacin exist in the blood. The absorption half-life of acemetacin is 0.86h, the elimination half-life is 2.62h, and the peak plasma concentration is 1.49μg/ml. More than 99% of metabolites are excreted in urine, mainly indomethacin, des-p-benzoyl acemetacin and des-p-chlorobenzoyl indomethacin.
Clinical application of acemetacin:
For rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriatic arthritis, acute gouty arthritis, chronic polyarthritis, low back pain, sciatica and inflammation of joints, muscles or tendons, tenosynovitis, Bursitis, inflammation and swelling after surgery and blunt outer fingers, superficial phlebitis, or other vascular inflammation. Anti-inflammatory analgesic. Acetyl indomethacin is the prodrug of indomethacin, which becomes indomethacin through metabolism in the body to play a role. Due to the strong anti-inflammatory effect of this product, the damage to the mucous membrane of the gastrointestinal system is very small, so compared with indomethacin, the treatment range is wider. It has anti-inflammatory and analgesic effects, and is used for rheumatoid arthritis, osteoarthritis, etc. Non-steroidal anti-inflammatory analgesics can obviously inhibit inflammation. It is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, myofibroblastitis, sciatica, etc.
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